Friday, May 21, 2021

Study solves mystery of how amyloid beta forms in brain nerve cells -- ScienceDaily

From Publisher: ScienceDaily



Tallia Storm goes braless in a stylish green suit at outdoor screening of Wonder Woman 1984 |

And Tallia Storm looked sensational as she attended an outdoor screening of film Wonder Woman 1984 at the Honourable Artillery Company in London on Thursday.

The Scottish singer, 22, ensured all eyes were on her as she flaunted her cleavage and went braless under a striking emerald green suit.

Tallia exuded confidence as she hit the red carpet and worked all her angles for the camera ahead of the screening in celebration of the launch of Hideaway Cinema.

She flaunted her ample cleavage in the plunging blazer, which also boasted stylish shoulder pads and pockets on each side.

Not forgetting her accessories, Tallia toted a small black handbag and added a little extra height to her sizzling frame with a pair of heels.

The blonde beauty wore her long tresses down, letting them cascade over one shoulder, and completed her look with a touch of pink lipstick.

Tallia was also seen getting a picture with young actress Lilly Aspell who played a young Diana, who is also Gal Gadot's character, in the Wonder Woman films.

From Publisher: Mail Online



Can SARS-CoV-2 cause amyloidosis? - Eminetra

New research released as a preprint of bioRxiv * The server describes the results of an analysis of the role that the virus played in amyloid formation and its subsequent health effects on various organs and organisms as a whole.

Severe Acute Respiratory Syndrome Long Covid by many scientists upset by the potential for millions of chronic debilitating sequelae after an apparently acute infection with coronavirus 2 (SARS-CoV-2) It is being researched. Much is still unknown about these long-term consequences.

SAA proteins come in many forms. Hexamers are a biologically active form that carries lipids around the body during inflammation. Monomers are susceptible to enzymatic cleavage and form small fragments that form amyloid fibrils.

Amyloidosis causes inflammation, clot formation, and tissue and organ damage. Renal failure and coagulation events are common in these patients.

Second, the most common SAA1-76 fragment can switch between two structural motifs. One rapidly degrades and lowers SAA levels, but quickly aggregates and the other protects against proteolysis. If amyloid formation is slower than amyloid degradation, the former predominates.

Under acidic conditions that promote amyloid formation, protected forms are more abundant. This scenario, or failure of SAA amputation, causes amyloidosis. Such failures can be caused by the destabilization of the functional SAA hexamer induced by SARS-CoV-2. There is a high probability of reaggregation of SAA fragments. Or the stability of SAA fibrils has been improved.

Current computational studies have examined all three possibilities, with a particular focus on the effects of viral proteins rather than viral genetic material. The focus was on short sequences of proteins that are likely to interact with SAA to form amyloid.

One such is the 9-residue SK9 segment on the envelope protein that easily interacts with SAA. SARS-CoV homologous proteins have been shown to interfere with amyrin aggregation.

Researchers first concluded that when SK9 binds to the SAA hexamer, it competitively inhibits the binding of the SAA protein chain and reduces stability. This promotes monomer formation by hexamer decomposition.

From Publisher: Eminetra



Alzheimer protein APP regulates learning and social behavior in the healthy brain: Beyond

To investigate the role of the APP protein family in the development and functionality of the nervous system, Prof. Müller's research group used mice as a model organism, which had been genetically engineered to block the production of all APP family proteins. Close examination of their brains revealed that the loss of APP during brain development led to malformations in the layered structure of the hippocampus -- an essential brain region for memory formation. "We observed that the absence of APP led to impaired neuronal wiring and a decrease in the number of synaptic connections. It also greatly reduced communication between nerve cells and severely affected the animal's performance in behaviour tests that assess learning," says Ulrike Müller, who heads the department of Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University.

Materials provided by University of Heidelberg . Note: Content may be edited for style and length.

From Publisher: ScienceDaily



Fashionably Fit at 50+ | Entertainment | montgomerynews.com

If you're leading up to or have hit age 50, you might be feeling like you're in a fashion predicament all of a sudden and find yourself questioning what's in your wardrobe.

Are my wedge sneakers still age-appropriate? Are skinny jeans too trendy for me? Is it OK to show a little cleavage?

These questions might lead you to feel out of touch with your personal sense of style and might even be doing a number on your level of self-confidence.

You could call it a fashion identity crisis of sorts. It might be especially applicable now that the U.S. is starting to open back up again and ease mask policies which means you might come across more occasions where you have to trade in your comfy quarantine sweats for an outfit that has you feeling more put together, whether it's for dinner out at a restaurant, attending a wedding or a backyard cookout.

According to research published by the American Psychological Association in their Journal of Personality and Social Psychology, you're supposed to have a higher level of self-esteem as you age, which peaks at age 60. This might leave you wondering why in the world clothing choices now feel complicated at a time when you should be at your prime to feel the most comfortable in your own skin.

The good news is that you're not alone and with a little guidance from a local fashion expert, you will be well on your way to getting back to dressing with confidence instead of hesitance,

Juli Cleaver, owner of Bella Jules in West Reading, weighed in on the topic while she was on a business buying trip in California where she was scoping out the latest fashion trends.

One thing she highlighted that's big this season is bold shoulders and sleeve details. Because things like to sag as we age, such as the skin under the arms, these features can help curb any arm insecurities.

From Publisher: Montgomery News



No, Science Clearly Shows That COVID-19 Wasn't Leaked From A Wuhan Lab

A new conspiracy theory, promoted by Sen. Rand Paul, vilifies Dr. Fauci and attempts to tie him to ... [+] the notion that the novel coronavirus SARS-CoV-2 was engineered in and leaked from the Wuhan Institute for Virology. The scientific evidence says otherwise on all counts.

The conspiracy, of course, is that China, and specifically the Wuhan Institute of Virology, genetically engineered this novel strain of coronavirus, SARS-CoV-2, to specifically wreak havoc on human populations. Depending on which particular incarnation of this conspiracy you listen to, it can involve:

Those are the claims — some with a grain of truth behind them, others which are completely bogus — being made against the natural origins of SARS-CoV-2, the virus that causes COVID-19. Now that we know what's being claimed, let's take a look at the actual truth.

The science of what can be done in virology, with modern techniques, is quite impressive. But what the conspiracy attests must have happened reaches far beyond the capabilities of even the most advanced research teams in the world.

The first red flag that should leap out at you, but perhaps only if you have some knowledge of virology to begin with, is the very idea that you could "know" what certain mutations would do — i.e., that you'd know what you'd create and what effect it would have on humans — without extensive testing in humans themselves.

Nobel prize winner Dr. Paul Nurse poses with a DNA molecule and a genetic sequence. The fact that we ... [+] can sequence a genome and can make modifications to an organisms genetic code is a remarkable achievement, but it doesn't stop nature from doing what it's always done. (David Jones/PA Images via Getty Images)

India's total number of COVID cases has now crested 25 million, with many cities such as Kolkata ... [+] facing emergency situations. We believe it is largely due to two factors: viral load exposure and genetic predispositions, that certain individuals have severe reactions to COVID-19 infections while others are virtually asymptomatic. (Indranil Aditya/NurPhoto via Getty Images)

The thing is this: there are all sorts of reasons behind why mutations occur. There are very common ones, like point mutations, deletions, or insertion mutations. But there are other types of mutations that occur as well: duplications, inversions, deletion-insertion combinations, and repeat expansions, among others. Finding an uncommon type of mutation in SARS-CoV-2 is no more evidence that a human intervened than it is to claim divine intervention for a human born with six digits on their hands and/or feet.

A sequenced genetic analysis of the UK variant of the novel coronavirus. The location of the change ... [+] in the viral genome is marked by the stitches. (Sebastian Gollnow/picture alliance via Getty Images)

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From Publisher: Forbes



Why WandaVision Reinvented Scarlet Witch's MCU Costume

Prior to the transformation at the end of WandaVision , Scarlet Witch's MCU costumes changed repeatedly. She was mostly in civilian clothes for Avengers: Age of Ultron , so her true superhero look didn't come until Captain America: Civil War . The scarlet-colored corset and long jacket became what Wanda wore in Avengers: Infinity War and Avengers: Endgame . It wasn't until the conclusion of WandaVision that she got her new outfit that reinvents Scarlet Witch's look for the MCU again.

Scarlet Witch's new MCU costume is a major departure from the character's classic costume. However, WandaVision still managed to include an homage to Wanda's original look thanks to Olsen. The actress was relieved to know she wouldn't have to wear Scarlet Witch's original comic costume when she first joined the MCU. This is because Scarlet Witch's leotard comic costume is quite revealing. After playing the character for so long, though, Olsen was the one who pushed for WandaVision 's Halloween version of the costume to go as far as it did. With co-star Paul Bettany wearing a cheap version of Vision's classic look, Olsen wanted to do the same with Scarlet Witch at last.

Cooper Hood is a news and feature writer for Screen Rant. He joined Screen Rant in late 2016 following a year-long stint with MCU Exchange, which came after first developing an MCU blog of his own. He graduated college in 2016 with a Bachelor's degree in Media & Public Communication, with a minor in Media Production. Cooper's love for movies began by watching Toy Story and Lion King on repeat as a child, but it wasn't until The Avengers that he took an invested interest in movies and the filmmaking process, leading him to discover the world of film journalism. Every year Cooper looks forward to seeing the latest blockbusters from the likes of Marvel, DC, and Star Wars, but also loves the rush to catch up on Oscar films near the end of the year. When he isn't writing about or watching new releases, Cooper is a fantasy football obsessive and looking to expand his Blu-Ray collection – because physical media is still king! Follow Cooper on Twitter @MovieCooper.

From Publisher: ScreenRant



From Nudity To Gay Rights: Here's Why These 10 Celebs Were Banned From Countries

Celebrities from across the world have been stopped from entering or performing in other countries, for various reasons. From racist remarks, to sexist decisions, here are 10 celebs who were banned from countries and why.

She had a scheduled concert in 2007, which she cancelled due to the protests over her clothes and performances. According to the BBC, "Female performers at Malaysian concerts are required by government rules to cover up from shoulders to knees, with no cleavage showing." And so Beyoncé cancelled the concert, because allegedly, she wouldn't even be allowed to dance on stage.

The singer was banned from China for his 'bad behaviour' in 2017. And similarly stopped from performing in Argentina in 2016 for allegedly beating a photographer in 2013, and stealing his money and gear. The singer was also accused of disrespecting Argentina's flag. Justin was also reported to be banned from Disneyland for a bit, for allegedly punching Mickey Mouse in the crotch, years ago. Ouch.

In 2009, Miley was banned in China when she posted a racist picture of herself, making what appeared to be slanted eyes. Chinese foreign minister, Yang Jiechi made a statement soon after saying, "Miss Cyrus has made it clear she is no friend of China or anyone of East Asian descent. We have no interest in further polluting our children's minds with her American ignorance."

According to reports that surfaced in 2015, Salman couldn't travel to Britain after the Supreme Court cancelled a court order that had put on hold his five year jail term in the 1998 poaching case. However, in 2017, he finally performed in UK after a 12-year hiatus, so we're guessing the ban was lifted or exceptions were made.

Reportedly, because Katy wore a sunflower dress during a performance in Taipei in 2015, and even waved the Taiwanese flag during the concert, she was banned in China in 2017. The reason for the outrage was that the sunflower had been adopted by anti-China protesters, and so her dress was deemed anti-national by China.

this is y'all woke palestine queen? Gigi out here mocking Asian people. i would say she's cancelled but she never started. rat @GiGiHadid pic.twitter.com/b6wj5k1sXE

After his film, Seven Years in Tibet , was a roaring success, the actor faced a ban in China which lasted for over 20 years - up until 2016. All because he played the part of an Austrian mountain climber, Heinrich Harrer, who befriends the Dalai Lama during the period of China's takeover of Tibet.




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