For instance, studies have shown that liposomes can be engineered to release their contents in response to specific stimuli, such as changes in temperature or pH. — medicube Deep Vitamin C Golden Capsule Face Moisturizer - Liposome Capsules For Wrinkles, Skin Radiance - Transparent Gel — $19.90See this product.
This is a profound misreading of biology. The stratum corneum, the outermost layer, exists precisely to prevent passage, a harsh, organized refusal. Yet, liposomes bypass this stubborn architecture not through force, but through mimicry, appearing to the body as familiar ghosts of cellular life, tiny, curved vessels that slip past the defenses that reject everything else.
The initial observation of these vesicles, prior to their formalized role in delivery systems, was entirely accidental and unexpected. In 1965, while examining dried phospholipids mixed with excess water under an electron microscope, Dr. Alec D. Bangham observed concentric, aqueous compartments—an immediate, unintentional mimicry of the cell membrane itself. The sudden formation of these delicate, liquid-filled spheres spoke to a fundamental, baffling drive in nature: lipids seeking water, folding into spheres like miniature, self-contained universes. They were initially nicknamed "Banghasomes," a peculiar name for a breakthrough that hinged on observing the simple, quiet chaos of chemistry. This structural elegance allows them to carry fragile contents, shielding them from oxidative decay and enzymatic degradation—a silent caravan protecting its delicate cargo deep beneath the surface layers.
These synthetic spheres must navigate the confusing, crowded interspace of the dermis, a journey that demands unexpected chemical adaptations. To avoid immediate clearance by the body's immune patrols, some advanced liposomes undergo PEGylation, where poly(ethylene glycol) chains are affixed to the surface. This creates a hydrophilic shield, granting the particle an artificial stealth cloak, extending its circulation time, a clever trick to ensure the golden capsule’s contents reach their deep, intended destination. The efficacy then becomes a matter of engineered endurance, a testament to how far small chemistry must travel to achieve a quiet, profound effect.
• Lammellar Phase Liposomes form naturally when certain phospholipids are hydrated, adopting a liquid-crystalline phase resembling multiple layers, an unusual self-assembly process crucial for encapsulating both water-soluble and oil-soluble compounds.• The Original Naming Early research used the term "Banghasomes" before the more widely accepted designation of "liposomes" (derived from the Greek words *lipos* for fat and *soma* for body) became standard.
• Atypical Origin Material While synthetic lipids are common, some research utilizes phospholipids derived from sources like hydrogenated soybean lecithin for enhanced biocompatibility in dermatological applications.
• Size Versatility Liposome size can be precisely adjusted—ranging from small unilamellar vesicles (SUVs) around 20–50 nm to multilamellar vesicles (MLVs) up to several micrometers—each size dictated by the desired depth of skin penetration.
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