Lizzie Cundy ensured she caught the eye on Thursday as she made her latest glamorous appearance in London .
The former WAG, 52, stood out in a vibrant red minidress with a plunging neckline as she made her way into Mayfair's upmarket Arts Club.
Fully exposing her cleavage, the outfit inevitably commanded attention during a photo opportunity outside the Dover Street address before she made her way through its double doors.
Lizzie added to her look with a pair of smart Louboutin boots, while a tasteful black leather handbag and heavily tinted sunglasses rounded things off.
Arriving in typically extravagant style, the brunette skipped from her car before getting a welcome kiss on the cheek from the venue's friendly doorman.
Lizzie's latest outing comes as she prepares to launch a new vegetarian cookbook after embracing a meat free diet during lockdown.
Pia Miller glows in a $1940 cleavage-baring top after rumours she secretly wed Patrick Whitesell
Rumours have been swirling that Pia Miller secretly tied the knot with her fiance Patrick Whitesell after she sported a diamond band on her left hand wedding finger.
On Wednesday, the 37-year-old stunned in a low-cut cleavage-baring top by Khaite, which costs an eye-watering $1940.
And over the the last few weeks, the Australian actress has convinced fans she's secretly married the multimillionaire Hollywood agent, 56.
Gossip: Pia fuelled rumours of a secret marriage last month when she flashed a diamond band on her left wedding finger in this selfie taken in Cabo, Mexico, considered one of the ultimate honeymoon destinations
Secretly married? She later posted this picture of her fiancé Patrick Whitesell, 56, appearing to wear a gold wedding ring
Eagle-eyed fans were quick to notice the accessory, with one commenting: 'Hello Mr and Mrs P' with a love-heart emoji.
Last month, the Chilean-born star shared a photo to Instagram of herself holidaying in Cabo, Mexico , considered one of the ultimate honeymoon destinations.
Megan Fox shows off cleavage during solo outing...
Two nights after her boyfriend Machine Gun Kelly snuck out of Delilah's with his assistant Olivia Stone, Megan Fox grabbed dinner solo at BOA Steakhouse in West Hollywood on Saturday.
But the Hollywood couple were pictured back together on Sunday afternoon following a sushi lunch date at Nobu Malibu.
The Tennessee-born 34-year-old - who maintains her youthful glow with help from Dr. Simon Ourian - will next celebrate the pop-punk rocker's 31st birthday this Thursday.
Cleavage alert! Two nights after her boyfriend Machine Gun Kelly snuck out of Delilah's with his assistant Olivia Stone, Megan Fox (pictured) grabbed dinner solo at BOA Steakhouse in West Hollywood on Saturday
'They are very much in love and have a strong and intense relationship. Her divorce is moving along, and they are hashing out custody details.'
Megan previously indicated she separated from the 47-year-old father of her three sons in November 2019 and officially filed for divorce from him on November 25.
'MGK (born Colson Baker) is slowly getting to know the kids and everything is going well with that,' the insider noted.
AAG’s approach to case: There was marked cleavage among SC judges - Business Recorder
During the proceeding, a clear division was visible among the judges sitting on the left and right sides of Justice Bandial, who is heading a 10-member larger bench, which comprises Justice Maqbool Baqar, Justice Manzoor Ahmed Malik, Justice Mazhar Alam Khan Miankhel, Justice Sajjad Ali Shah, Justice Mansoor Ali Shah, Justice Yahya Afridi, Justice Qazi Muhammad Amin Ahmed, and Justice Aminud Din Khan.
The bench heard the review petitions of Justice Qazi Faez Isa, the Supreme Court Bar Association (SCBA), the Pakistan Bar Council (PBC), and the provincial bar councils and associations, and the petition of Sarina Isa against the apex court's judgment on the Presidential Reference.
AAG Amir Rehman resumed his arguments and read the judgments with a view to strengthening his point of view that the apex court can give direction to the FBR against Sarina Isa.
The judges on the right side of the chair objected to the reading out of the whole judgments, instead of citing the relevant portions or providing the bullet points of his submission due to paucity of time. However, the judges on the left side of Justice Bandial were of the view that time is no issue and Amir Rehman should be given full time.
Justice Maqbool Baqar and Justice Mazhar Alam Khan Miankhel were of the opinion that the AAG may read only the relevant portions of the judgments or provide the list of the case laws.
He told the AAG; "We are hard pressed for time, so only read the relevant portion. We didn't allow the other side to read out the full judgments."
Justice Muneeb, however, said: "We are not racing against time," adding that "there is no issue of time."
Justice Qazi Ameen, who was also sitting on the left side of Justice Bandial, asked Amir Rehman to "argue in the manner you wish but just be mindful of time."
At that time, Justice Mazhar Alam told the AAG that keeping in view the fact that one member of the bench (Justice Manzoor) is retiring at the end of this month, he should provide the list of judgments.
Scientists provide new insights into the citric acid cycle | EurekAlert! Science News
IMAGE: Lydia Steffens and Eugenio Pettinato (University of Münster, left) and Thomas M. Steiner (TUM, right) in the laboratory; the three doctoral students share first authorship of the Nature publication. In... view more
These findings could also be of interest for biotechnology. With the knowledge that autotrophic organisms using this "backward cycle" depend on the CO? concentration, scientists can apply it to more efficiently convert substrates into value-added products.
The scientists wanted to understand what factor determines whether the citric acid cycle runs "forwards" or "backwards" in the bacteria. Cultivating the bacteria under different conditions, they noticed that the growth of these organisms was highly dependent on the CO? concentration in the gas phase. In detail, the high CO? concentration was needed to allow the function of another important enzyme, pyruvate synthase. This enzyme is responsible for assembling acetyl coenzyme A (acetyl-CoA), the product of the "reversed cycle". The high CO? concentration drives the pyruvate synthase reaction in the direction of carboxylation and the entire cycle backwards, enabling CO? to be converted into biomass. The studied Hippea maritima and Desulfurella acetivorans were able to grow very well at 20% and 40% CO? in the gas phase but only moderately at 5% CO?, and no growth was possible at 2% or 1% CO?. As a control, the scientists studied another autotrophic bacterium Desulfobacter hydrogenophilus, which uses the energetically more expensive ATP-citrate lyase version of the reversed citric acid cycle. In this bacterium, growth was not affected by the CO? concentration.
The "backward cycle" that uses citrate synthase for citrate cleavage cannot be bioinformatically predicted, as it does not have the key enzymes whose presence can be used as a marker for the functioning of the pathway. Therefore, as an identifying feature for bioinformatic analyzes, the scientists used the detected high levels of citrate synthase in these bacteria's protein cocktail. Using a special analysis tool, the researchers were able to predict the production levels of individual proteins. With this trick, it was possible to predict the functioning of the "backward cycle" for inorganic carbon fixation in many anaerobic bacteria.
The scientists also showed that no gene regulation was necessary for switching from the oxidative ("forward") to the reductive ("reverse") direction. "This means that the cells can react very quickly on the availability of the carbon source in the environment" says Ivan Berg. "They use either the reductive direction to fix CO?, if the concentration of CO? is high, or the oxidative direction, if another carbon source is available."
The methods used in the study were mass spectrometry and 13C-isotope analyses, enzyme measurements, protein quantification as well as media and amino acid analyses using chromatographic and spectrometric methods (LC/MS or GC/MS). With bioinformatic methods, they examined the occurrence of certain nucleotide base combinations (codons) in order to make predictions about the production of individual proteins.
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
Madonna, 62, puts on a busty display as she dances on her hotel balcony in a lacy Burberry
The Material Girl showcased her sex appeal donning a studded trench a cleavage-heavy bustier from the legendary British fashion house, which debuted its Fall/Winter 2021 collection in London that same day.
Madge, 62, was in full performance mode as vamped it up for the camera while on the balcony of a posh hotel.
After sitting for hair and makeup, the Madame X diva danced around in a provocative lace and leather look which could barely contain her ample curves.
First, she crouched down seductively to take a few snapshots, offering a smoldering stare at the camera while a fancy cocktail sat close by.
The star didn't hold back, seen licking her lips for the camera while layers of 80s style necklaces tickled her décolletage.
Then it was time to move, as Madge got up and twirled around with her song I Don't Search I Find bumping in the background.
Thigh's the limit! As she danced, the star's platinum locks swept around while her coat flew back to reveal her toned stems, which were wrapped in thigh-high boots
Ayala Pharmaceuticals Announces First Patient Dosed in Phase 1 Clinical Trial of AL102 in
AL102 is an oral small molecule that inhibits gamma secretase. Inhibition of gamma secretase prevents the cleavage and shedding of BCMA, which are ubiquitously expressed on MM cells. Preclinical data have demonstrated that treatment with AL102 increases expression of membrane-bound BCMA on the surface of MM cells and could enhance activity of WVT078.
The Phase 1, open-label, multicenter trial of AL102 in combination with Novartis' WVT078 is currently enrolling patients with relapsed and/or refractory multiple myeloma who have received two or more standard of care lines of therapy including an IMID, a proteasome inhibitor, and an anti-CD38 agent. The first-in-human dose escalation trial is designed to assess the safety, tolerability and recommended dose regimen(s) of WVT078 alone and in combination with AL102. In addition, the trial will assess preliminary anti-MM response and characterize the pharmacokinetics and immunogenicity of WVT078 alone and in combination with AL102.
Under the terms of the option and license agreement established in December 2018, Novartis is responsible for the conduct and expenses of any trials of AL102 in combination with their BCMA-targeting agents, as well as potential commercialization, in multiple myeloma. Ayala retains worldwide license rights to AL102 in all other indications.
About AL102 AL102 is a potent, selective and oral gamma secretase inhibitor (GSI). AL102 is currently being developed for the treatment of desmoid tumors, as well as in combination with Novartis' BCMA-targeting agents for the treatment of multiple myeloma (MM).
About WVT078 WVT078 is a bispecific antibody that engages both BCMA and CD3, resulting in the recruitment of cytotoxic T cells that target BCMA-positive MM cells.
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How to identify which proteases are cleaving a protein of interest | Imperial News | Imperial
The paper ‘ Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1 ’ details work which was carried out when Dr Lovell was an ICB CDT PhD student in the Tate group and was completed in collaboration with the group of Professor John Hooper at the University of Queensland , Australia.
During his PhD, Scott was awarded an RSC travel mobility grant to fund a short-term research project in the lab of Professor Judith Clements at the Translational Research Institute in Brisbane, Australia. During this placement Scott was introduced to co-first author Dr. Thomas Kryza and Professor Hooper. The project was initiated after an informal discussion between Dr Lovell and Dr Kryza – a real testament to the success of international placements for PhD students and to early career researchers forming interdisciplinary collaborations.
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