Sunday, April 4, 2021

Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix

logo
From Publisher: Docwire News



Many things were taking place:

Erica Mena Blows Fans' Minds With A Massive Cleavage - See Her Daring Outfit | Celebrity Insider

Erica Mena managed to blow her fans' minds with an amazing outfit that she flaunted in her latest pic. Check it out here.

RELATED: Safaree Posts New Video Showing George Floyd In Custody And The Police 'Beating The Sh*t Out Of Him'

Someone posted this: 'Well said.. u mighT wanNa fix the Top of yoUr DreSs AmiGa🔥⛽💯' and another follower said: 'You are really beautiful😍'

One other follower said: 'Did @safaree mess up or Sum Ting'?🤔 I hope not! Couple Fav❤️🤞🏾' and one other follower posted this: '🔥always beautiful no matter what Erica Mena ❤️'

'I'm so excited guys! The Royal Throne by @luxuryyoni is my new Best Friend! I absolutely LOVE V Steaming with their products. By far the best thing I've ever owned is my @luxuryyoni Royal Throne V Spa Steam Seat. It's left me feeling so relaxed and rejuvenated. Ladies, if you haven't tried it you are missing out. Pls treat yourself you deserve it! I have a discount code: Erica15, to get 15% Off because you NEED to get one. Get the V Steam herbs, Luxury Diva Gown and candle too so you can EXPERIENCE an amazing V Steam in the comfort of your home 💞 @luxuryyoni #thankyouluxuryyoni #vsteam #vspa,' Erica wrote.

Someone said: 'Is this a legit company? Cause I order from another company that you used to advertise and I still haven't received my order or any reimbursement.'

Erica Mena showed off the amazing gown that her daughter, Safire Majesty has. It's a version of her mother's wedding dress and it is beyond amazing.




The scientists who say the lab-leak hypothesis for SARS-CoV-2 shouldn't be ruled out | MIT

Nikolai Petrovsky was scrolling through social media after a day on the ski slopes when reports describing a mysterious cluster of pneumonia cases in Wuhan, China, caught his eye. It was early January 2020, and Petrovsky, an immunologist, was at his vacation getaway in Keystone, Colorado, which is where he goes most years with his family to flee the searingly hot summers at home in South Australia. He was soon struck by an odd discrepancy in how the pneumonia cases were portrayed. Chinese authorities and the World Health Organization were saying there was nothing to worry about, but locals in the area, he says, were posting about "bodies being stretchered out of houses in Wuhan and police bolting apartment doors shut."

As Petrovsky considered whether SARS-CoV-2 might have emerged in lab cultures with human cells, or cells engineered to express the human ACE2 protein, a letter penned by 27 scientists appeared suddenly on February 19 in the prestigious medical journal The Lancet. The authors insisted that SARS-CoV-2 had a natural origin, and they condemned any alternate hypotheses as conspiracy theories that create only "fear, rumors, and prejudice."

Petrovksy says he found the letter infuriating. Conspiracy theorists is "the last thing we were," he says, "and it looked to be pointing at people like us."

Last month, a team of international scientists completed a month-long visit to Wuhan to investigate SARS-CoV-2's origins. Convened by the WHO, and closely monitored by Chinese authorities, the team concluded initially that a lab leak was so unlikely that further investigations of it were unnecessary. The WHO's director general later walked that statement back, claiming that "all hypotheses remain open and require further analysis and studies." A group of 26 scientists, social scientists, and science communicators—Petrovksy among them—have now signed their own letter arguing that WHO investigators lacked "the mandate, the independence, or the necessary accesses" to determine whether or not SARS-CoV-2 could have been the result of a laboratory incident.

The WHO investigation follows a year during which debates over SARS-CoV-2's origins turned increasingly acrimonious. Chinese officials were, and still are, unwilling to provide information that might settle lingering questions about where the virus came from, and in the absence of critical data, expert views coalesced around two competing scenarios: one that a lab leak was plausible and needed more scrutiny, and another that SARS-CoV-2 had almost certainly spilled over from nature and that the odds of a lab leak were so remote that the possibility could essentially be taken off the table. Those insisting on a natural origin say the virus lacks genetic features that would show it to have been deliberately engineered. But it's also possible that SARS-CoV-2 evolved naturally in the wild before it was brought into a lab to be studied, only to subsequently escape. The Wuhan Institute of Virology, which many see as the likeliest site of a breakout, houses one of the largest collections of coronaviruses in the world.

David Relman, a microbiologist at Stanford University, says a lab leak was never the subject of a "fair and dispassionate discussion of the facts as we know them." Instead, tempers soon began to flare as those calling for a closer look at possible lab origins were dismissed as conspiracy theorists spouting misinformation. Election-year politics and growing Sinophobic sentiments only added to the tensions. Attacks on Asian-Americans had been escalating since the pandemic began, and with then-president Trump fuming about a "Chinese virus," many scientists and reporters became "cautious about saying anything that might justify the rhetoric of his administration," says Jamie Metzl, a senior fellow at the Washington, DC–based Atlantic Council, an international affairs think tank.

The challenge will be convincing enough outliers to get vaccinated so that America can return to normality.

The vitriol also obscures a broader imperative, Relman says, which is that uncovering the virus's origins is crucial to stopping the next pandemic. Threats from both lab accidents and natural spillovers are growing simultaneously as humans move steadily into wild places and new biosafety labs grow in number around the world. "This is why the origins question is so important," Relman says.

"We need a much better sense about where to place our resources and effort," he adds. And if a lab release for SARS-CoV-2 looks plausible, Relman says, "then it absolutely deserves a whole lot more attention."

From Publisher: MIT Technology Review



The origin of SARS-CoV-2 furin cleavage site remains a mystery

The SARS-CoV-2 is a betacoronavirus, and is most closely related to the bat SARS-related coronavirus (SARSr-CoV) represented by the genome sequence RaTG13, which shares 96% identity with the former. This has made the bat virus the most probable precursor of the virus in current circulation.

Furin acts on substrates with single or paired basic residues during the processing of proteins within cells. Such a polybasic furin cleavage site is found in various proteins from many viruses, including Betacoronavirus Embecoviruses, and the Merbecovirus. However, within the betacoronaviruses of the sarbecovirus lineage B, this type of site is unique to SARS-CoV-2.

The study used a bioinformatic approach using the genomic data available on the National Center for Biotechnological Information (NCBI) databases, to identify the origin of the furin cleavage site.

The three genomic fingerprints used to identify these matches include fingerprint 1, in the orf1a RNA polymerase gene, including the nsp2 and nsp3 genes; fingerprint 2, at the beginning of S gene, covering the part encoding the N-terminal domain and the receptor-binding domain (RBD) that mediates attachment to the host cell receptor, the angiotensin-converting enzyme 2 (ACE2).; and fingerprint 3, the orf8 gene.

These fingerprints are distinctive to the three closely related coronaviruses only at the RNA level, but the amino acid sequences in the translated proteins are similar to other sarbecoviruses.

The sharing of these genomic sequences indicates their common ancestry, supported by other short sequence features, with one deletion and three insertions. All three strains show the same deletion-insertion pattern at the same four different locations in the spike gene.

The analysis of the phylogeny of these three strains showed that the first to diverge was the pangolin coronavirus, with the RatG13 being the closest. However, when only the spike is analyzed, there is a high similarity between the pangolin CoV, RaTG13 and SARS-CoV-2.

This may indicate the occurrence of recombination events between the Pangolin-CoV (2017) and RatG13 ancestors. This was followed by the shift of the pangolin CoV to pangolin hosts.

The furin cleavage site consists of four amino acids PRRA, which are encoded by 12 inserted nucleotides in the S gene. A characteristic feature of this site is an arginine doublet.

From Publisher: News-Medical.net



Many things were taking place:

Woman Turned Away From Paris Museum For Showing Too Much Cleavage

PARIS, June 23, 2020 -- Visitors wearing protective face masks visit the Musee d'Orsay as the ... [+] museum reopens to the public in Paris, France, June 23, 2020. The Musee d'Orsay (Orsay Museum) reopened its doors to the public on Tuesday after its shutdown as France entered a new phase of de-confinement with more measures to ease the coronavirus lockdown. (Photo by Gao Jing/Xinhua via Getty) (Xinhua/Gao Jing via Getty Images)

Paris' famed Musée d'Orsay has apologized to a woman who was refused entry because her dress was too low cut. The incident has again raised issues about the treatment of women in France, as well as a concern about creeping prudishness in a country once renowned for its libertine ways.

The woman at the center of the storm has thus far only identified herself as Jeanne. But her story flashed across social media a few days ago after she published an open letter on Twitter to the D'Orsay Museum about the incident.

In the letter, she explains that a museum employee told her she would have to cover herself if she wished to enter. "Arriving at the museum entrance, I didn't even have time to get out my ticket when the sight of my breasts and low-cut dress shocked the agent in charge of checking reservations," she wrote. She posted the letter along with a picture of the dress taken by a friend just a few hours earlier.

When the confrontation began, it was not immediately clear what the problem was. Museum employees were apparently feeling too embarrassed to explicitly explain the issue. It took several minutes of awkward looking and pointing before it finally became clear that they had taken issue with her cleavage.

By that time, Jeanne wrote she felt humiliated and refused to put on additional clothes. While employees kept insisting it was the rules, none could cite specifically which rules.

Among its collection, D'Orsay contains many famous nudes, which made the dust-up even more surprising to many observers. But it also fanned the conservation about prudish behavior that began a month ago when French police ordered a woman sunbathing topless on Mediterannean beach to cover herself.

Local officials later apologized and clarified that topless sunbathing was perfectly legal. The brouhaha even prompted Interior Minister Gérald Darmanin to tweet in support of going topless on the beaches.

logo
From Publisher: Forbes



Billie Eilish Shows Off Major Cleavage On Puppy's First Birthday

Billie Eilish is paying tribute to her bestest friend in the whole world -- her puppy! The "bad guy" singer took to Instagram to shower her furry friend with praise and love one year after she rescued the cute gray pit bull mix. Although she never revealed a name for the pit, the singer clearly made the dog part of the pack, along with her other rescue dogs, Misha and Pepper, and her pet tarantula.

"Happy birthday sweet boy," Billie Eilish captioned a photo of the pup on her Instagram Stories while showing off the last year of fun she has had with the pit bull mix. Eilish first revealed the dog last April during the pandemic when she admitted to having "failed" at fostering the dog as a rescue and just ended up adopting him.

The singer's photos, which included some curvy shots, showed how much her dog has grown over the year, along with how many snuggles he got from the star.

19-year-old Billie Eilish flaunted was seen in a much different look while hanging with her puppy, as she traded in her baggy fashion choices for cozy tops that revealed her ample assets.

It has been a change for the star, as she has opened up in recent months about growing up in the spotlight and learning to love her physical features.

From Publisher: The Blast



No comments:

Post a Comment

Featured Post

Limited Deals Price $399.99—Dyson Outsize Origin Cordless Vacuum, Nickel/Red.

Dyson Outsize Origin Cordles​s...

Popular Posts